Gap Junction Channel Protein Innexin 2 Is Essential for Epithelial Morphogenesis in theDrosophilaEmbryo
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چکیده
منابع مشابه
Gap junction channel protein innexin 2 is essential for epithelial morphogenesis in the Drosophila embryo.
Direct communication of neighboring cells by gap junction channels is essential for the development of tissues and organs in the body. Whereas vertebrate gap junctions are composed of members of the connexin family of transmembrane proteins, in invertebrates gap junctions consist of Innexin channel proteins. Innexins display very low sequence homology to connexins. In addition, very little is k...
متن کاملThe Drosophila gap junction channel gene innexin 2 controls foregut development in response to Wingless signalling.
In invertebrates, the direct communication of neighbouring cells is mediated by gap junctions, which are composed of oligomers of the innexin family of transmembrane proteins. Studies of the few known innexin mutants in Drosophila and C. elegans have shown that innexin proteins, which are structurally analogous to the connexins in vertebrates, play a major structural role as gap junctional core...
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Gap junctions mediate intercellular communication and are critical for development and nervous system function. Initially thought to function solely as stand-alone molecules, it has now been shown that a stomatin-like protein regulates a gap junction channel in Caenorhabditis elegans.
متن کاملImmunocytochemical study of gap junction-related protein, innexin 2, in Periplaneta americana (Blattodea: Blattidae)
Gap junctions are intercellular junction apparatus found in almost all multicellular animals and are involved in direct intercellular communication. Those of invertebrate animals consist of the innexin protein family. We developed antibodies against peptide fragments of Bombyx mori innexin 2, and examined tissues of Periplaneta americana by Western blotting, immunohistochemistry and immunoelect...
متن کاملHeteromerization of innexin gap junction proteins regulates epithelial tissue organization in Drosophila.
Gap junctions consist of clusters of intercellular channels, which enable direct cell-to-cell communication and adhesion in animals. Whereas deuterostomes, including all vertebrates, use members of the connexin and pannexin multiprotein families to assemble gap junction channels, protostomes such as Drosophila and Caenorhabditis elegans use members of the innexin protein family. The molecular c...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2004
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e04-01-0056